Life Sciences 1996-01-01

Neuroprotective effect of 4'-(4-methylphenyl)-2,2':6',2-terpyridine trihydrochloride, a novel inducer of nerve growth factor.

K Yamamoto, R Yoshikawa, S Okuyama, Y Takahashi, Y Karasawa, N Hino, T Miyoshi, H Araki, K Hanabusa, H Shirai, K Tomisawa

Index: Life Sci. 59(25-26) , 2139-46, (1996)

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Abstract

We have identified 4'-(4-methylphenyl)-2,2':6',2-terpyridine: trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS701, when administered 30 min after induced cerebral ischemia, neuroprotective effects on delayed neuronal death in Mongolian gerbils were evident. The neuroprotective effects of SS701 against ischemia-induced delayed neuronal death are attributed to stimulation of the production of NGF.