9-(Aminoalkyl)-8-hydroxyadenines: Preparation, mechanism of formation and use in affinity chromatography of S-adenosyl-L-homocysteine hydrolase

…, J Kohoutová, A Merta, I Votruba

Index: Holy, Antonin; Kohoutova, Jitka; Merta, Ales; Votruba, Ivan Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 2 p. 459 - 477

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Citation Number: 15

Abstract

Abstract Bromine reacts with 9-(2-hydroxyethyl)-(Va), 9-(3-hydroxypropyl)-(Vb), 9-(2- hydroxypropyl)-(Vc), 9-(2, 3-dihydroxypropyl)-(Vd), 9-(1, 3-dihydroxy-2-propyl)-(Ve), 9-threo- (2, 3-dihydroxybutyl)-(Vf) and 9-threo-(2, 3, 4-trihydroxybutyl) adenine (Vg) to give 8- bromoadenine derivatives (Vl). Reaction of compounds Vl with ammonia results in intramolecular cyclization to five-and six-membered cyclic esters which are ...