Organic Letters 2006-12-07

One-pot synthesis of 2,3-dihydro-pyrrolopyridinones using in situ generated formimines.

Geoffrey Deguest, Alice Devineau, Laurent Bischoff, Corinne Fruit, Francis Marsais

Index: Org. Lett. 8 , 5889, (2006)

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Abstract

A novel one-pot methodology is described for the synthesis of functionalized pyrrolopyridinones using in situ generated formimines and an ortho-lithiated pyridinecarboxamide species. Depending on the reaction conditions, this procedure allows versatile access to aminomethylated pyridinecarboxamides, 2,3-dihydro-pyrrolopyridinones, or 1,1-dialkylated 2,3-dihydro-pyrrolopyridinone derivatives. [reaction: see text]