Bioorganic & Medicinal Chemistry Letters 2001-01-08

p38 kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas.

A M Redman, J S Johnson, R Dally, S Swartz, H Wild, H Paulsen, Y Caringal, D Gunn, J Renick, M Osterhout, J Kingery-Wood, R A Smith, W Lee, J Dumas, S M Wilhelm, T J Housley, A Bhargava, G E Ranges, A Shrikhande, D Young, M Bombara, W J Scott

Index: Bioorg. Med. Chem. Lett. 11(1) , 9-12, (2001)

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Abstract

Inhibitors of the MAP kinase p38 are potentially useful for the treatment for osteoporosis, arthritis, and other inflammatory diseases. A series of thienyl, furyl, and pyrrolyl ureas has been identified as potent p38 inhibitors, displaying in vitro activity in the nanomolar range.