Synlett

Microwave-assisted aminocarbonylation of aryl bromides at low carbon monoxide pressure

F Cardullo, D Donati, G Merlo, A Paio, E Petricci…

Index: Cardullo, Francesca; Donati, Daniele; Merlo, Giancarlo; Paio, Alfredo; Petricci, Elena; Taddei, Maurizio Synlett, 2009 , # 1 p. 47 - 50

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Citation Number: 6

Abstract

Abstract An efficient and rapid procedure for microwave-assisted aminocarbonylation of aryl bromides and iodides at low CO pressure, using (PPh 3) 2 PdCl 2 or Pd (OAc) 2 as catalysts is reported. Different reaction conditions have been tested in order to carry out the reaction even on less nucleophilic anilines such as 2-chloro-4-nitroaniline, allowing a rapid access (in 20-30 min) to several diverse arylamides in good yields.