Tetrahedron

Synthesis of functionalized α-amino-phosphine oxides and-phosphonates by addition of amines and aminoesters to 4-phosphinyl-and 4-phosphonyl-1, 2-diaza-1, 3- …

F Palacios, D Aparicio, Y López, M Jesús

Index: Palacios, Francisco; Aparicio, Domitila; Lopez, Yago; De Los Santos, Jesus M. Tetrahedron, 2005 , vol. 61, # 11 p. 2815 - 2830

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Citation Number: 27

Abstract

1, 2-Diaza-1, 3-butadienes derived from phosphine oxides and phosphonates and with optically active substituents on N-1 and C-3 are obtained by 1, 4-elimination from chlorohydrazonoalkyl-phosphine oxides and-phosphonates in the presence of bases. Michael addition (1, 4-addition) of ammonia, aliphatic and aromatic amines and aminoesters to these azo-alkenes gives functionalized α-amino-phosphine oxides and-phosphonates.