Chemical Communications 2012-01-07

Direct use of dioxygen as an oxygen source: catalytic oxidative synthesis of amides.

Wei Wei, Xiao-Yu Hu, Xiao-Wei Yan, Qiang Zhang, Ming Cheng, Jian-Xin Ji

Index: Chem. Commun. (Camb.) 48(2) , 305-7, (2012)

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Abstract

The first transition-metal-catalyzed direct oxidative synthesis of amides by using dioxygen as an oxygen source has been developed under mild conditions, in which DBU was used as the key additive. The present methodology, which utilizes dioxygen as an oxidant and oxygen source and cheap copper salts as catalysts, opens up an interesting and attractive avenue for the synthesis of amide functionality.This journal is © The Royal Society of Chemistry 2012