Organic Letters 2004-06-10

Expedient protocol for solid-phase synthesis of secondary and tertiary amines.

Christian A Olsen, Matthias Witt, Jerzy W Jaroszewski, Henrik Franzyk

Index: Org. Lett. 6 , 1935-1938, (2004)

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Abstract

[reaction: see text] An expedient solid-phase synthetic approach to secondary and tertiary amines was developed. The protocol employs conversion of resin-bound amino alcohols to the corresponding iodides, followed by iodide displacement with primary or secondary amines or with unprotected amino alcohols. This two-step procedure, affording products in good to excellent yields, is suitable for solid-phase synthesis of polyamines.