Organic Letters 2012-04-06

Highly efficient synthesis of N-substituted isoindolinones and phthalazinones using Pt nanowires as catalysts.

Linyan Shi, Lei Hu, Jiaqing Wang, Xueqin Cao, Hongwei Gu

Index: Org. Lett. 14(7) , 1876-9, (2012)

Full Text: HTML

Abstract

A series of N-substituted isoindolinones have been successfully synthesized through the reductive C-N coupling and intramolecular amidation of 2-carboxybenzaldehyde and amines. This one-pot synthesis gives excellent yields using ultrathin Pt nanowires as catalysts under 1 bar of hydrogen. These unsupported catalysts can also be used for the synthesis of phthalazinones in high yield when hydrazine or phenyl hydrazine is used instead of amines.