Organic Letters 2011-02-04

Asymmetric organocatalytic double-conjugate addition of malononitrile to dienones: efficient synthesis of optically active cyclohexanones.

Xue-ming Li, Bo Wang, Jun-min Zhang, Ming Yan

Index: Org. Lett. 13(3) , 374-377, (2011)

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Abstract

9-Amino-9-deoxyepiquinine efficiently catalyzed the double-conjugate addition of malononitrile to dienones. A number of 1,1,2,6-tetrasubstituted cyclohexanones were prepared in good yields, diastereoselectivities, and excellent enantioselectivities.