Sequential Hiyama Coupling/Narasaka Acylation Reaction of (E)??1, 2??Disilylethene: Rapid Assembly of α, β??Unsaturated Carbonyl Motifs

C Thiot, C Mioskowski, A Wagner

Index: Thiot, Carine; Mioskowski, Charles; Wagner, Alain European Journal of Organic Chemistry, 2009 , # 19 p. 3219 - 3227

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Citation Number: 6

Abstract

Abstract The synthesis and application of (E)-1, 2-disilylethene 5 as a central functional building block in a sequential Hiyama coupling/Narasaka acylation reaction are described. Its use in the rapid and versatile construction of α, β-unsaturated carbonyl motifs found in a number of polyunsaturated natural products has been demonstrated. It was observed that due to the differential intrinsic reactivity of the two carbon–silicon bonds, this bis- ...