Archiv der Pharmazie (Weinheim) 2009-10-01

Synthesis and cytotoxic evaluation of 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate.

Aurora Molinari, Alfonso Oliva, Claudia Ojeda, José M Miguel del Corral, M Angeles Castro, Carmen Cuevas, Arturo San Feliciano

Index: Arch. Pharm. (Weinheim) 342(10) , 591-9, (2009)

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Abstract

Several new 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate (NHQ-DA) have been prepared by chemical modifications of the Diels-Alder adduct of alpha-myrcene and 1,4-benzoquinone. All these new compounds and precursors have been evaluated in vitro for their cytotoxicity against cultured human cancer cells of MB-231 breast-adeno carcinoma, A-549 lung carcinoma, and HT-29 colon carcinoma. GI(50) values ranged in and below the micromolar concentration level.