Tetrahedron

Synthesis and preliminary evaluation of novel analogues of quindolines as potential stabilisers of telomeric G-quadruplex DNA

C Le Sann, J Huddleston, J Mann

Index: Le Sann, Christine; Huddleston, Jonathan; Mann, John Tetrahedron, 2007 , vol. 63, # 52 p. 12903 - 12911

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Citation Number: 16

Abstract

Telomeric DNA is a potential selective target for cancer therapy since the tumour-associated enzyme telomerase regulates telomere maintenance in most cancer cells. The 3′ single- stranded ends of telomeric DNA can be folded into quadruplex structures by appropriate small molecules. We describe the preparation of a new class of 2, 7-disubstituted 10H- indolo [3, 2-b] quinolines with enhanced selectivity for the stabilisation of quadruplex DNA ...