Bioorganic & Medicinal Chemistry Letters 2010-06-15

Towards Gram-positive antivirulence drugs: new inhibitors of Streptococcus agalactiae Stk1.

Mayalen Oxoby, François Moreau, Lionel Durant, Alexis Denis, Jean-Marie Genevard, Vanida Vongsouthi, Sonia Escaich, Vincent Gerusz

Index: Bioorg. Med. Chem. Lett. 12th ed., 20 , 3486-3490, (2010)

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Abstract

A structure-activity relationship study from a screening hit and structure-based design strategy has led to the identification of bisarylureas as potent inhibitors of Streptococcus agalactiae Stk1. As this target has been directly linked to bacterial virulence, these inhibitors can be considered as a promising step towards antivirulence drugs.Copyright 2010 Elsevier Ltd. All rights reserved.