Abstract An efficient domino cyclization method for the construction of aza- podophyllotoxin/aza-conidendrin derivatives has been established. Reactions of different dienes with aryl halides in the presence of a palladium catalytic system produced different kinds of podophyllotoxin derivatives through a highly regioselective C [BOND] H functionalization. Treatment of dienes with aryl halides that have electron-withdrawing ...
![7-phenyl-9-p-tolyl-7,7a,9,10,10a,11-hexahydronaphtho[2,1-f]isoindol-8-one Structure](https://image.chemsrc.com/caspic/442/1220294-77-8.png)