Stereoselective C-alkylation of di-imine macrocycles: a versatile route to a series of meso-dialkyl-substituted macrocyclic tetramines

…, PG Owston, R Peters, PA Tasker, RW Turner

Index: Henrick, Kim; Judd, Patricia M.; Owston, Philip G.; Peters, Roger; Tasker, Peter A.; Turner, Ralph W. Journal of the Chemical Society, Chemical Communications, 1983 , # 21 p. 1253 - 1254

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Abstract

Macrocycles containing two o-iminoanilino units undergo stereoselective C-alkylation on treatment with Grignard reagents or lithium alkyls to give the meso-dialkyl-substituted macrocyclic tetra-amines. ... As part of a much wider programme1 of design and synthesis of tetra-azamacrocycles we have recently considered syste- matic methods for the preparation of a range of macrocyclic te t ra-ami nes which incorporate a1 kyl su bst it uen ts. Often the most troublesome ...