Tetrahedron

A novel strategy to the synthesis of 4-anilinoquinazoline derivatives

Z Wang, C Wang, Y Sun, N Zhang, Z Liu, J Liu

Index: Wang, Zheng; Wang, Cuiling; Sun, Yanni; Zhang, Ning; Liu, Zhulan; Liu, Jianli Tetrahedron, 2014 , vol. 70, # 4 p. 906 - 913

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Citation Number: 8

Abstract

Abstract A novel approach to prepare 4-anilinoquinazoline derivatives based on the transformation of indoline-2, 3-dione to formamidine was developed. The processes with this approach are simple, efficient, and environmentally friendly. The efficiency of this approach was evaluated by synthesizing 17 4-anilinoquinazolines and comparing the obtained yields with those achievable through conventional synthetic methods. It was the first time that ...