1-Phenylcycloalkylamine derivatives. II. Synthesis and pharmacological activity

A Kalir, H Edery, Z Pelah, D Balderman…

Index: Kalir; Edery; Pelah; Balderman; Porath Journal of medicinal chemistry, 1969 , vol. 12, # 3 p. 473 - 477

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Citation Number: 111

Abstract

A series of S, K-substituted 1-arylcycloheuylamines was prepared mainly by the reaction of an arylmagnesiuni hromide and 1-dialkylaminocyclohexanecarbonitrile. As the cyclopentyl analog could not be obtained by this way, condensation of 1-phenylcyclopentylamine with pentamethylene dibromide in DIIF was tried with success. These compounds were tested for their psychopharmacological properties. 1-[l-(2-Thienyl) cyclohesyl] piperidine (16) was ...