Biochemical and Biophysical Research Communications 2012-06-15

The anti-tumor effect of cross-reacting material 197, an inhibitor of heparin-binding EGF-like growth factor, in human resistant ovarian cancer

Xiao-han Tang, Suo Deng, Meng Li, Mei-song Lu

Index: Biochem. Biophys. Res. Commun. 422(4) , 676-80, (2012)

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Abstract

Highlights ► HB-EGF over-expression in A2780/Taxol, A2780/CDDP cells and the matched xenografts. ► CRM197 induces enhanced apoptosis in A2780/Taxol and A2780/CDDP cells. ► CRM197 arrests A2780/Taxol and A2780/CDDP cells at G0/G1 phase. ► CRM197 suppressed the A2780/Taxol and A2780/CDDP growth of xenografts.