Drug Discovery Today 2005-05-15

Keynote review: Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists

Jos H.M. Lange, Chris G. Kruse

Index: Drug Discov. Today 10 , 693-702, (2005)

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Abstract

The proven clinical efficacy of the CB1 cannabinoid receptor antagonist rimonabant in obesity and its further therapeutic potential has given a tremendous impetus to the discovery of novel CB1 antagonists.