Chemical Communications 2012-03-11

Efficient synthesis of 2,5-disubstituted tetrazoles via the Cu2O-catalyzed aerobic oxidative direct cross-coupling of N-H free tetrazoles with boronic acids.

Yu Li, Lian-Xun Gao, Fu-She Han

Index: Chem. Commun. (Camb.) 21th ed., 48 , 2719-2721, (2012)

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Abstract

We present a new protocol that allows for the synthesis of 2,5-disubstituted tetrazoles via the direct coupling of N-H free tetrazoles and low toxic boronic acids in the presence of only a catalytic amount of Cu(2)O (5 mol%) as catalyst and 1 atm of environmentally benign O(2) as oxidant, without the need for other additives. This method represents a simple, green, and atom-efficient synthesis of 2,5-disubstituted tetrazoles.This journal is © The Royal Society of Chemistry 2012