Transplantation Proceedings 2010-01-01

The Effects of Gabexate Mesilate on the Microsurgical Reconstruction of the Hepatic Artery in Living Donor Liver Transplantation

S. Miyagi, Y. Enomoto, S. Sekiguchi, N. Kawagishi, S. Satomi, S. Miyagi, Y. Enomoto, S. Sekiguchi, N. Kawagishi, S. Satomi

Index: Transplant. Proc. 42(10) , 4158-60, (2010)

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Abstract

Objectives Microsurgical reconstruction of hepatic artery is essential but require challenging techniques especially for living donor liver transplantation (LDLT), because the recipient artery is short, located deep, and usable vessel grafts are limited. Furthermore, hepatic artery thrombosis (HAT) can be a lethal complication. Therefore, we began the systemic administration of gabexate mesilate, a strong serine protease inhibitor. It has often been effective to treat disseminated intravascular coagulation. The purpose of this study was to examine the effects of gabexate mesilate on the microvascular reconstruction.