Silicon Heterocyclic Compounds. III. Silicon-Substituted Spirobarbiturates1

RJ Fessenden, JG Larsen, MD Coon…

Index: Fessenden,R.F. et al. Journal of Medicinal Chemistry, 1964 , vol. 7, p. 695 - 698

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Citation Number: 15

Abstract

A group of silicon-containing spirobarbiturates of the general structures I1 and I11 have been prepared by the classical reaction between a substituted malonic ester, 3, 3- dicarbethosy-l-silacycloalkane, and a urea or thiourea. The tosicities and the EDso for the loss of the righting reflex have been evaluated for these compounds.