Identification of novel allosteric nonpeptidergic inhibitors of the human cytomegalovirus-encoded chemokine receptor US28

…, MHP Verheij, J Victorina, MJ Smit, IJP de Esch…

Index: Vischer, Henry F.; Hulshof, Janneke W.; Hulscher, Saskia; Fratantoni, Silvina A.; Verheij, Mark H.P.; Victorina, Jane; Smit, Martine J.; de Esch, Iwan J.P.; Leurs, Rob Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 675 - 688

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Citation Number: 20

Abstract

Human cytomegalovirus (HCMV) is a widespread human pathogen, possessing onco- modulatory properties. Constitutive signaling of the HCMV-encoded chemokine receptor US28 and its ability to bind a broad spectrum of chemokines might facilitate HCMV- associated tumor progression. Novel nonpeptidergic chemotypes were identified as neutral antagonists or inverse agonists on US28, that allosterically inhibit chemokine binding to ...