Phytotherapy Research 2004-08-01

Two ellagitannins from the leaves of Terminalia triflora with inhibitory activity on HIV-1 reverse transcriptase.

V Martino, J Morales, J J Martínez-Irujo, M Font, A Monge, J Coussio

Index: Phytother Res. 18(8) , 667-9, (2004)

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Abstract

The bioassay- guided fractionation of the aqueous extract of Terminalia triflora leaves afforded punicalin and 2-O-galloylpunicalin, isolated for the first time from this species. These compounds showed inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner. Punicalin showed an IC(50) of 0.11 microg/ml (0.14 microM) and 2-O-galloylpunicalin an IC(50) of 0.10 microg/ml (0.11 microM).Copyright (c) 2004 John Wiley & Sons, Ltd.