Drug and Chemical Toxicology 2003-05-01

Four week feeding toxicity study with phenylphosphinic acid in rats.

E Maria Donner, Gerald L Kennedy, Judith S Stadler

Index: Drug Chem. Toxicol. 26(2) , 125-33, (2003)

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Abstract

Phenylphosphinic acid was fed in graded concentrations of either 0 (control), 100, 1,000, or 10,000 ppm to rats for 28 days. These concentrations provided average daily doses of 8, 76, and 779 mg/kg (males) and 9, 83, and 859 mg/kg (females). No signs of adverse response were detected at any concentration up to the highest levels tested, 10,000 ppm or 779 (male) or 859 (female) mg/kg. Parameters measured were clinical signs, growth, neurobehavior, ophthalmology, and clinical and anatomical pathology. Phenylphosphinic acid is very low in toxicity following 31 days of feeding to the rat.