Potential Anticancer Agents. LXXVIII. 1 Nonclassical Antimetabolites. IV. 2 Synthesis of Compounds Related to 4-(Iodoacetamido) salicylic Acid, an Exo-Alkylating …

BR Baker, WW Lee, AP Martinez, LO Ross…

Index: Baker,B.R. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 3283 - 3295

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Citation Number: 16

Abstract

The various S-acylaminosalicylic acids that form groups 1 and 2 were prepared by the general method of condensing the appropriate acyl chloride with the appropriate aminosalicylic acid in aqueous solution containing excess sodium bicarbonate. Thus, 4-(6- iodopropionamido) salicylic acid (XII), 4-(a-iodopropionamido) salicylic acid (XIII), and 4-(a- chloro-a-phenylacetamido) salicylic acid (XIV) 9 were readily obtained from 4- ...