Electrophilic intramolecular cyclization of functional derivatives of unsaturated compounds: V. Cyclization of anilides of styrylacetic acids in polyphosphoric acid

RI Vas'kevich, AI Vas'kevich, IY Daniluk…

Index: Vas'Kevich; Daniluk, I. Yu.; Vovk Russian Journal of Organic Chemistry, 2013 , vol. 49, # 8 p. 1175 - 1181 Zh. Org. Khim., 2013 , vol. 49, # 8 p. 1192 - 1198,7

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Citation Number: 3

Abstract

Abstract Anilides of styrylacetic acids at heating in polyphosphoric acid undergo an intramolecular cyclization giving 1, 5-diarylpyrrolidin-2-ones, 5-aryl-1, 3, 4, 5-tetrahydro-2 H- benzazepin-2-ones, and 5-(3-fluorophenyl) dihydrofuran-2 (3 H)-one, where the ratio of the products depends on the character of the aromatic substituents in the amide and styrene fragments of the substrate.