Bioscience Reports 1988-04-01

An experiment in enzyme evolution. Studies with Pseudomonas aeruginosa amidase.

P H Clarke, R Drew

Index: Biosci. Rep. 8(2) , 103-20, (1988)

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Abstract

The regulation of amidase synthesis in P. aeruginosa is under positive control. This review describes the experimental evolution of amidase and its regulator protein for the hydrolysis of novel substrates and experiments to elucidate the mechanism of the control system.