Drug Discovery Today 2010-12-01

Lyotropic liquid crystal systems in drug delivery.

Chenyu Guo, Jun Wang, Fengliang Cao, Robert J Lee, Guangxi Zhai

Index: Drug Discov. Today 15 , 1032-1040, (2010)

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Abstract

Lyotropic liquid crystal systems, such as reversed bicontinuous cubic and hexagonal mesophases, are attracting more and more attention because of their unique microstructures and physicochemical properties. Various bioactive molecules such as chemical drugs, peptides and proteins can be solubilized in either aqueous or oil phase and be protected from hydrolysis or oxidation. Furthermore, several studies have demonstrated sustained release of bioactive molecules from reversed cubic and hexagonal mesophases. This article gives an overview of recent advances and current status of reversed cubic and hexagonal mesophases, especially with respect to their preparation methods and applications in the field of drug delivery. In addition, potential problems and possible future research directions are highlighted.Copyright © 2010 Elsevier Ltd. All rights reserved.