Chemical & Pharmaceutical Bulletin 2005-10-01

Synthesis of new dihydropyrazines with DNA strand-breakage activity.

Hiroshi Maruoka, Nobuhiro Kashige, Fumio Miake, Tadatoshi Yamaguchi

Index: Chem. Pharm. Bull. 53(10) , 1359-61, (2005)

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Abstract

Treatment of 1,2-cyclohexanedione with 1,2-diamines, e.g. ethylenediamine and cis-(and trans-)1,2-diaminocyclohexane, caused [4+2] cyclocondensation to give the corresponding dihydropyrazine derivatives (compounds 1-6). They exhibited stronger DNA strand-breakage activity than that of dihydropyrazines, which has already been reported in previous papers.