International Journal of Peptide and Protein Reseach 1988-01-01

Beta-subunit of baboon chorionic gonadotropin. Continuous flow Fmoc-polyamide synthesis of the C-terminal 37-peptide.

C R Wu, J D Wade, G W Tregear

Index: Int. J. Pept. Protein Res. 31(1) , 47-57, (1988)

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Abstract

The synthesis of a 37-peptide fragment derived from the carboxyl terminal of the beta-subunit of baboon chorionic gonadotropin has been accomplished by the continuous flow Fmoc-polyamide solid phase method. The use of N alpha-fluorenylmethoxy-carbonyl-glutamine with its sidechain protected by the 4,4'-dimethoxybenzhydryl group enabled successful incorporation of this residue onto a hydroxymethyl linkage agent without apparent side reaction.