Chemical Communications 2010-12-14

Iron-catalyzed synthesis of glycine derivatives via carbon-nitrogen bond cleavage using diazoacetate.

Yoichiro Kuninobu, Mitsumi Nishi, Kazuhiko Takai

Index: Chem. Commun. (Camb.) 46(46) , 8860-2, (2010)

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Abstract

Treatment of tertiary amines with diazoacetate in the presence of a catalytic amount of an iron salt, FeCl(3), in ethanol gave glycine derivatives. In this reaction, a carbon-nitrogen single bond of the amine was cleaved.