Conversion of 5,8,11-eicosatrienoic acid to leukotrienes C3 and D3.
S Hammarström
Index: J. Biol. Chem. 256 , 2275, (1981)
Full Text: HTML
Abstract
5,8,11-Eicosatrienoic acid was converted by mouse mastocytoma cells stimulated with ionophore A23187 to two slow reacting substances. These were characterized by spectroscopy and by chemical and enzymatic degradations as two geometrical isomers of 5-hydroxy-6-S-glutathionyl-7,9,11-eicosatrienoic acid (E,E,Z; leukotriene C3 and E,E,E; 11-trans-leukotriene C3). Corresponding cysteinylglycine compounds (leukotriene D3 and 11-trans leukotriene D3) were obtained from the leukotriene C3 isomers by treatment with kidney gamma-glutamyl transpeptidase. The biological effects of leukotrienes C3 and D3, on the isolated guinea pig ileum, were approximately the same as of leukotrienes derived from arachidonic acid.
Related Compounds
| Structure | Name/CAS No. | Molecular Formula | Articles |
|---|---|---|---|
 |
Leukotriene C3
CAS:77209-77-9 |
C30H49N3O9S |
|
Contractile activities of structural analogs of leukotrienes...
1981-05-01 [Proc. Natl. Acad. Sci. U. S. A. 78 , 3195, (1981)] |
|
Distribution and metabolism of 3H-labeled leukotriene C3 in ...
1982-01-10 [J. Biol. Chem. 257(1) , 531-5, (1982)] |
|
Metabolism of leukotriene C3 in the guinea pig. Identificati...
1981-09-25 [J. Biol. Chem. 256(18) , 9573-8, (1981)] |
|
Contractile activities of several cysteine-containing leukot...
2009-01-01 [Eur. J. Pharmacol. 86(2) , 207-15, (1982)] |
|
Metabolism of leukotriene C3.
1982-01-01 [Adv. Prostaglandin. Thromboxane. Leukot. Res. 9 , 83-101, (1982)] |