e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis of Erythrina and related alkaloids. XVI Diels-Alder approach: Total synthesis of dl-erysotrine, dl-erythraline, dl-erysotramidine, dl-8-oxoerythraline and their 3 …
T SANO, JUN TODA, N KASHIWABA…
Index: Sano; Toda; Kashiwaba; et al. Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 2 p. 479 - 500
Total synthesis of erythrinan alkaloids was achieved by a strategy based on the Diels-Alder reaction of activated butadienes to a dioxopyrroline. The reaction of isoquinolinopyrrolinedione (15) with 1, 3-bis-O-substituted butadienes proceeded in a regiospecific and stereoselective manner to give erythrinan derivatives (20) and (21). Lithium borohydride reduction of the adduct (20) or (21), followed by acid hydrolysis ...
