Abstract 6, 7-Dimethoxy-3, 4-dihydroisoquinolin-1-ylacetonitrile in the enamine form readily reacts with acyl iso (thio) cyanates affording in high yields 1, 2-fused oxo-and thioxodihydropyrimidoisoquinolines and thiouracyloisoquinolines. The reaction of the enamine with primary amines of diverse classes in the presence of 2 equiv of formaldehyde resulted in 1, 2-fused N-substituted tetrahydropyrimidinoisoquinolines whose yields ...
![2-cyano-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide Structure](https://image.chemsrc.com/caspic/032/98841-65-7.png)
