Synthesis of D, L-γ-hydroxyphosphinothricin, a potent new inhibitor of glutamine synthetase

DM Walker, JF McDonald, EW Logusch

Index: Walker, Daniel M.; McDonald, John F.; Logusch, Eugene W. Journal of the Chemical Society, Chemical Communications, 1987 , p. 1710 - 1711

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Citation Number: 10

Abstract

A flexible synthesis of D, L-γ-hydroxyphosphinothricin (GHPPT), a potent inhibitor of the enzyme glutamine synthetase, is described which features silicon-mediated addition of ethyl methylphosphinate to benzyl 2-benzyloxy-carbonylamino-4-oxobutyrate; selective deprotections yield the title compound and various derivatives.