Bioorganic & Medicinal Chemistry Letters 2012-06-01

Remarkably fast and selective aromatization of Hantzsch esters with MoOCl4and MoCl5: A chemical model for possible biologically relevant properties of molybdenum-containing enzymes

Mladen Litvić, Maja Regović, Karolina Šmic, Marija Lovrić, Mirela Filipan-Litvić, Mladen Litvić, Maja Regović, Karolina Smic, Marija Lovrić, Mirela Filipan-Litvić, Mladen Litvić, Maja Regović, Karolina Smic, Marija Lovrić, Mirela Filipan-Litvić

Index: Bioorg. Med. Chem. Lett. 22(11) , 3676-81, (2012)

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Abstract

Selective aromatization of Hantzsch esters with MoOCl4 or MoCl5 is described. The reaction employing MoOCl4 proceeds smoothly under reflux of acetonitrile within 1–20min and the products of high purity were isolated in good-to-excellent yields (70–99%). From the obtained results it is proposed that molybdenum-containing enzymes also participate in the metabolism of 1,4-dihydropyridine drugs.