CNS??Agent Precursor: A Simple and Efficient Synthesis of an Antipsychotic Drug Fluanisone

AV Narsaiah, B Nagaiah…

Index: Narsaiah, A. Venkat; Nagaiah; Devi, B. Karuna Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 4 p. 829 - 832

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Citation Number: 5

Abstract

Abstract An efficient synthesis of antipsychotic drug fluanisone has been carried out in seven steps with an overall yield of 32.2%. The synthesis was started from 4-fluorobenzaldehyde. All the reactions were very clean and the isolation of products was very easy.

 Related Synthetic Route
N/A Structure

1402042-57-2

N/A

~91%

1-(4-p-Fluorophenyl-4-hydroxybutyl)-4-o-methoxy-phenylpiperazine Structure

857-62-5

1-(4-p-Fluoroph...

4-Fluorobenzaldehyde Structure

459-57-4

4-Fluorobenzaldehyde

~%

1-(4-p-Fluorophenyl-4-hydroxybutyl)-4-o-methoxy-phenylpiperazine Structure

857-62-5

1-(4-p-Fluoroph...

1‐(4‐fluorophenyl)‐but‐3‐en‐1‐ol Structure

86718-78-7

1‐(4‐fluorophen...

~%

1-(4-p-Fluorophenyl-4-hydroxybutyl)-4-o-methoxy-phenylpiperazine Structure

857-62-5

1-(4-p-Fluoroph...

1‐[1‐(benzyloxy)‐but‐3‐enyl]‐4‐fluorobenzene Structure

1143515-07-4

1‐[1‐(benzyloxy...

~%

1-(4-p-Fluorophenyl-4-hydroxybutyl)-4-o-methoxy-phenylpiperazine Structure

857-62-5

1-(4-p-Fluoroph...

4-(benzyloxy)-4-(4-fluorophenyl)-butan-1-ol Structure

1402042-55-0

4-(benzyloxy)-4...

~%

1-(4-p-Fluorophenyl-4-hydroxybutyl)-4-o-methoxy-phenylpiperazine Structure

857-62-5

1-(4-p-Fluoroph...

4-(benzyloxy)-4-(4-fluorophenyl)-butanal Structure

1402042-56-1

4-(benzyloxy)-4...

~%

1-(4-p-Fluorophenyl-4-hydroxybutyl)-4-o-methoxy-phenylpiperazine Structure

857-62-5

1-(4-p-Fluoroph...

1-(4-p-Fluorophenyl-4-hydroxybutyl)-4-o-methoxy-phenylpiperazine Structure

857-62-5

1-(4-p-Fluoroph...

~92%

fluanisone Structure

1480-19-9

fluanisone


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