Bulletin of the Chemical Society of Japan

A New Method for the Preparation of Piperazines. II. Preparation of N, N′-Disubstituted Piperazines

K Nakajima

Index: Nakajima,K. Bulletin of the Chemical Society of Japan, 1961 , vol. 34, p. 655 - 659

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Citation Number: 6

Abstract

However, the distillation must be carried out under fairly low pressure, say 10 mmHg, in order to obtain the Oacetyl compounds in a pure form, because they have a tendency to undergo decomposition over 200 C to piperazine derivatives. For any practical purpose, the Oacetyl compounds need not be isolated. The yields of piperazines are 70 to 95 per cent. In the preparation of the compounds IIIi to III15 from the corresponding Oacetyl compounds, ...