Bioorganic & Medicinal Chemistry Letters 2010-06-01

Modulation of 11β-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles

Scott P. Webster, Margaret Binnie, Kirsty M.M. McConnell, Karen Sooy, Peter Ward, Michael F. Greaney, Andy Vinter, T. David Pallin, Hazel J. Dyke, Matthew I.A. Gill, Ines Warner, Jonathan R. Seckl, Brian R. Walker

Index: Bioorg. Med. Chem. Lett. 20(11) , 3265-71, (2010)

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Abstract

The synthesis and biological activity of a series of 1,5-substituted 1H-tetrazoles that modulate 11β-HSD1 activity is reported.