Organic letters

Selective monolithiation of dibromobiaryls using microflow systems

A Nagaki, N Takabayashi, Y Tomida, J Yoshida

Index: Nagaki, Aiichiro; Takabayashi, Naofumi; Tomida, Yutaka; Yoshida, Jun-ichi Organic Letters, 2008 , vol. 10, # 18 p. 3937 - 3940

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Citation Number: 60

Abstract

Selective monolithiation of dibromobiaryls, such as 2, 2′-dibromobiphenyl, 4, 4′- dibromobiphenyl, 2, 7-dibromo-9, 9-dioctylfluorene, 2, 2′-dibromo-1, 1′-binaphthyl, and 5, 5′-dibromo-2, 2′-bithiophene, with 1 equiv of n-butyllithium followed by the reaction with electrophiles was achieved using a microflow system by virtue of fast micromixing and precise temperature control. Sequential introduction of two different electrophiles based ...