Tetrahedron

Efficient preparation of secondary aminoalcohols through a Ti (IV) reductive amination procedure. Application to the synthesis and antibacterial evaluation of new 3β- …

C Salmi, C Loncle, Y Letourneux, JM Brunel

Index: Salmi, Chanaz; Loncle, Celine; Letourneux, Yves; Brunel, Jean Michel Tetrahedron, 2008 , vol. 64, # 19 p. 4453 - 4459

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Citation Number: 19

Abstract

An efficient method for the synthesis of various secondary aminoalcohols through a titanium (IV) isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, different ketones gave the expected products in moderate to excellent yields up to 89% in numerous cases. A series of 3β-N-[hydroxyalkyl] aminosteroid derivatives were prepared according to this methodology and evaluated for their in vitro antimicrobial properties ...