International Journal of Clinical Pharmacology Research 1988-01-01

Bacampicillin, amoxycillin and talampicillin concentrations in bronchial secretions.

S Schönwald, I Beus, V Car, V Mahovlić, T Jeren, F Plavsić, V Brlić

Index: Int. J. Clin. Pharmacol. Res. 8(4) , 263-6, (1988)

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Abstract

There are references in the literature describing the influence of bronchial inflammation on the antibiotic concentration in bronchial secretions, including netilmicin concentrations in the bronchial secretion of patients undergoing tracheotomy. Three semi-synthetic penicillins are compared--bacampicillin, amoxicillin and talampicillin--administered frequently in the treatment of various respiratory infections. The three antibiotics were administered successively for two days each, in the same patient, irrespective of other drugs. At the same time the cytologic evaluation of the degree of bronchial inflammation was done. The antibiotic concentrations in bronchial secretions and in sera were measured at the same time. The results showed that the concentration of antibiotics in bronchial secretions of patients undergoing tracheotomy was proportional to the degree of bronchial inflammation. Among the semi-synthetic penicillins investigated the highest degree of concentration in the bronchial secretion was obtained after the bacampicillin.