Chemistry Letters

Oxidative Deamination of Various Primary Amines to the Corresponding Carbonyl Compounds by Using N-tert-Butylphenylsulfinimidoyl Chloride.

J Matsuo, A Kawana, Y Fukuda, T Mukaiyama

Index: Matsuo, Jun-Ichi; Kawana, Asahi; Fukuda, Yoshio; Mukaiyama, Teruaki Chemistry Letters, 2001 , # 7 p. 712 - 713

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Citation Number: 14

Abstract

Various linear and non-linear primary amines were oxidatively deaminated to afford the corresponding carbonyl compounds in good to excellent yields by the following procedure:(i) initial formation of their N-cyclohexylated or N-mesylated derivatives,(ii) subsequent oxidation of these derivatives by using N-tert-butylphenylsulfinimidoyl chloride (1) and DBU,(iii) one-pot acid-hydrolysis of thus formed imines to carbonyl compounds.