Arzneimittel-Forschung 1989-02-01

[Metabolic studies of 5-ethyl-2'-deoxyuridine with liver extract, liver cells and liver cell culture].

A Buchele, U Schloz, A Müller-Wellensiek, W Voelter

Index: Arzneimittelforschung 39(2) , 220-2, (1989)

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Abstract

5-Ethyl-2'-deoxyuridine (EtUdR) was converted with rat liver extract, rat liver cells and rat liver cell cultures into its metabolites 5-ethyluracil and 5-(1-hydroxyethyl) uracil. The analytical identification of the metabolites as well as the investigation of the biotransformation process was performed by thin layer chromatography, autoradiography and high pressure liquid chromatography.