Advanced Materials (FRG) 2009-12-28

A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization.

Benjamin D Fairbanks, Michael P Schwartz, Alexandra E Halevi, Charles R Nuttelman, Christopher N Bowman, Kristi S Anseth

Index: Adv. Mater. 21(48) , 5005-10, (2009)

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Abstract

Step-growth, radically mediated thiol-norbornene photopolymerization is used to create versatile, stimuli-responsive poly(ethylene glycol)-co-peptide hydrogels The reaction is cytocompatible and allows for the encapsulation of human mesenchymal stem cells with a viability greater than 95%. Cellular spreading is dictated via three-dimensional biochemical photopatterning. Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.