Journal of medicinal chemistry

Bicyclic Homologs of Piperazine. VII. 1 Synthesis and Analgesic Activity of 3-Aralkenyl-8-propionyl-3, 8-diazabicyclo [3.2. 1] octanes

G Cignarella, E Occelli, E Testa

Index: Cignarella,G. et al. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 326 - 331

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Citation Number: 32

Abstract

Some of these com-25 derivatives were qxthesized ill which t, lie 8-aralkeiiyl group was vnrioii> ly modified. p (Jl1~ ldS exhibited ail analgesic pot, eiic)-romparable with that of 1. 111 the preccedirig paper of this sericls.'the synthesis of analgesic3:<-substituted 8- propio1iyl-X, 8-diazabicyclo-[3.2. l] oc. tanes was reported and the effect of the 3-and 8- substituenl oil the activity was discussed. It was observed that the greatest analgesic. ...