The Tohoku Journal of Experimental Medicine 2003-07-01

Antiviral activity of 2-amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one on poliovirus.

Akiko Iwata, Teruhide Yamaguchi, Kouei Sato, Ryutaro Izumi, Akio Tomoda

Index: Tohoku J. Exp. Med. 200(3) , 161-5, (2003)

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Abstract

2-Amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one (Phx), which was produced by the reaction of bovine hemoglobin with 2-amino-5-methylphenol, inhibited the proliferation of poliovirus in Vero cells between 0.25 microg/ml and 2 microg/ml with maximal antiviral acitivity at 1 microg/ml. These results suggest that Phx may be useful to prevent the proliferation of poliovirus infection.