Clinical Biochemistry 2005-01-01

Amoxicillin-associated interference in an HPLC–EC assay for urinary fractionated metanephrines: Potential pitfall in pheochromocytoma biochemical diagnosis

Sebastiano Barco, Maria Giannina Alpigiani, Gian Marco Ghiggeri, Marina Talio, Angelo Maffia, Gino Tripodi, Giuliana Cangemi

Index: Clin. Biochem. 47(15) , 119-21, (2014)

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Abstract

Objective Measurement of urinary fractionated metanephrines represents a first-line test for the biochemical diagnosis of pheochromocytoma. The high performance liquid chromatography coupled to electrochemical detection (HPLC–EC) assays used in the routine clinical laboratory can be subjected to analytical interferences by the presence of drugs or their metabolites. In this paper we describe the interference on urinary normetanephrine (uNMN) caused by amoxicillin.